Charles C Wykoff Selected Research

Macular Degeneration (Age-Related Maculopathy)

3/2024	Gene therapy for neovascular age-related macular degeneration by subretinal delivery of RGX-314: a phase 1/2a dose-escalation study.
3/2024	Real-World Safety Outcomes with Brolucizumab in Neovascular Age-Related Macular Degeneration: Findings from the IRIS® Registry.
3/2024	Impact of Anti-VEGF Treatment and Patient Characteristics on Vision Outcomes in Neovascular Age-related Macular Degeneration: Up to 6-Year Analysis of the AAO IRIS® Registry.
2/2024	Topographic analysis of local OCT biomarkers which predict progression to atrophy in age-related macular degeneration.
1/2024	Imaging Features of Retinal Vasculitis and/or Retinal Vascular Occlusion after Brolucizumab Treatment in the Postmarketing Setting.
11/2023	The effect of complement C3 or C5 inhibition on geographic atrophy secondary to age-related macular degeneration: A living systematic review and meta-analysis.
10/2023	Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials.
9/2023	BALATON and COMINO: Phase III Randomized Clinical Trials of Faricimab for Retinal Vein Occlusion: Study Design and Rationale.
7/2023	Archway Phase 3 Trial of the Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration 2-Year Results.
1/2023	Morphological characteristics of eyes with neovascular age-related macular degeneration and good long-term visual outcomes after anti-VEGF therapy.

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Charles C Wykoff Research Topics

Disease

50	Macular Degeneration (Age-Related Maculopathy) 03/2024 - 03/2013
50	Macular Edema 12/2023 - 01/2013
41	Diabetic Retinopathy (Retinopathy, Diabetic) 11/2023 - 07/2014
13	Retinal Vein Occlusion 09/2023 - 09/2014
11	Inflammation (Inflammations) 03/2024 - 01/2018
9	Geographic Atrophy 04/2024 - 01/2020
7	Retinal Vasculitis 03/2024 - 01/2017
7	Endophthalmitis (Ophthalmia) 09/2023 - 04/2011
7	Retinal Detachment (Retinal Detachments) 10/2022 - 01/2021
6	Atrophy 04/2024 - 01/2013
6	Hypoxia (Hypoxemia) 01/2022 - 06/2002
5	Retinal Perforations 01/2023 - 01/2010
4	Cataract (Cataracts) 07/2023 - 09/2010
4	Retinal Diseases 01/2023 - 01/2011
4	Ischemia 10/2022 - 01/2013
4	Edema (Dropsy) 01/2018 - 12/2014
3	COVID-19 01/2023 - 10/2020
3	Choroidal Neovascularization 05/2021 - 01/2016
3	Diabetes Mellitus 01/2021 - 06/2018
2	Choroidal Effusions 03/2024 - 01/2018
2	Cysts 01/2024 - 11/2017
2	Disease Progression 10/2023 - 02/2013
2	Blister (Bulla) 09/2023 - 01/2022
2	Central Serous Chorioretinopathy 11/2022 - 01/2009
2	Microaneurysm 11/2021 - 01/2017
2	Vascular Diseases (Vascular Disease) 01/2021 - 01/2020
2	Hypersensitivity (Allergy) 01/2020 - 01/2011
2	Neoplasms (Cancer) 05/2013 - 06/2002
1	Retinal Artery Occlusion 11/2023
1	Polypoidal Choroidal Vasculopathy 11/2022
1	Eye Diseases (Eye Disease) 01/2020
1	Uveitis 08/2019
1	Epilepsy (Aura) 02/2018
1	Stroke (Strokes) 01/2018
1	Myocardial Infarction 01/2018
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 12/2017

Drug/Important Bio-Agent (IBA)

45	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2024 - 01/2011
43	Retinaldehyde (Retinal)IBA 03/2024 - 02/2013
32	afliberceptIBA 11/2023 - 07/2014
27	Ranibizumab (Lucentis)FDA Link 09/2023 - 03/2013
16	Fluorescein (Funduscein)FDA LinkGeneric 10/2022 - 01/2013
12	brolucizumabIBA 03/2024 - 12/2018
11	Biomarkers (Surrogate Marker)IBA 02/2024 - 10/2019
6	Endothelial Growth FactorsIBA 09/2023 - 05/2017
5	salicylhydroxamic acid (SHAM)IBA 10/2023 - 01/2017
4	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2024 - 05/2017
4	Angiopoietin-2IBA 12/2023 - 01/2019
4	faricimabIBA 12/2023 - 01/2019
4	pegcetacoplanIBA 10/2023 - 01/2020
4	CytokinesIBA 06/2023 - 01/2021
4	N-acetyltryptophanamide (NATA)IBA 01/2023 - 12/2014
4	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 01/2021 - 01/2018
4	Fluocinolone Acetonide (Capex)FDA LinkGeneric 11/2020 - 01/2017
3	Complement System Proteins (Complement)IBA 11/2023 - 01/2022
2	Complement C3 (C3 Complement)IBA 11/2023 - 01/2020
2	PlacebosIBA 10/2023 - 10/2023
2	abicipar pegolIBA 01/2023 - 01/2020
2	Verteporfin (Visudyne)FDA Link 11/2022 - 01/2009
2	SuspensionsIBA 01/2021 - 01/2018
2	Povidone-Iodine (Betadine)FDA LinkGeneric 01/2020 - 01/2011
2	SteroidsIBA 01/2018 - 01/2009
2	Anti-Bacterial Agents (Antibiotics)IBA 07/2016 - 11/2011
2	Transcription Factors (Transcription Factor)IBA 10/2004 - 07/2004
2	Proteins (Proteins, Gene)FDA Link 06/2003 - 12/2002
1	SDDSIBA 04/2024
1	formycin diphosphate (FDP)IBA 01/2023
1	Vascular Endothelial Growth FactorsIBA 01/2023
1	Vascular Endothelial Growth Factor CIBA 01/2023
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 11/2022
1	Neurofibromin 2 (Merlin)IBA 01/2022
1	Capsules (Microcapsules)IBA 01/2022
1	Pentosan Sulfuric Polyester (Pentosan Polysulfate)FDA Link 01/2022
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2021
1	Immunoglobulins (Immunoglobulin)IBA 01/2021
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2021
1	Complement Inactivating AgentsIBA 01/2021
1	AngiopoietinsIBA 01/2021
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2020
1	IodineIBA 01/2020
1	Mydriatics (Cycloplegics)IBA 10/2019
1	frovatriptan (Allegro)FDA Link 02/2018
1	SiliconIBA 11/2017
1	Hemoglobins (Hemoglobin)IBA 09/2017
1	Vancomycin FDA LinkGeneric 01/2017

Therapy/Procedure

28	Therapeutics 11/2023 - 05/2013
17	Injections 03/2024 - 07/2014
12	Vitrectomy 03/2024 - 01/2010
12	Lasers (Laser) 10/2023 - 02/2013
9	Intravitreal Injections 09/2023 - 04/2011
7	Light Coagulation 10/2023 - 01/2017
4	Retreatment 10/2023 - 01/2018
2	Traction 04/2024 - 01/2022
2	Scleral Buckling 07/2022 - 01/2022
2	Vitreoretinal Surgery 01/2022 - 10/2020
2	Operative Surgical Procedures 01/2021 - 06/2017
1	Transplantation 09/2023
1	Cryotherapy (Therapy, Cold) 01/2021
1	Visual Prosthesis 12/2017
1	Glycemic Control 09/2017
1	Drug Therapy (Chemotherapy) 05/2017